HAP-SAMPLE2: data-based resampling for association studies with admixture.

Abstract excerpt

MOTIVATION: HAP-SAMPLE2 extends the functionality of the original HAP-SAMPLE tool for simulating genotype-phenotype data, now with features to handle population admixture and rare variant analysis. It allows users to define parameters such as disease prevalence and allele effect sizes for both common and rare variant simulations. RESULTS: HAP-SAMPLE2 provides an efficient means for simulating complex datasets,...

Topics

• Software
• Humans
• Genome-Wide Association Study
• Genotype
• Genetic Association Studies
• Polymorphism, Single Nucleotide