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Article

Expression of a neuroendocrine gene signature in gastric tumor cells from CEA 424-SV40 large T antigen-transgenic mice depends on SV40 large T antigen.

PloS one - 1 Jan 2012

Ihler Fritz, Vetter Elena Viviana, Pan Jie, Kammerer Robert, Debey-Pascher Svenja, Schultze Joachim L, Zimmermann Wolfgang, Enders Georg

Abstract excerpt

BACKGROUND: A large fraction of murine tumors induced by transgenic expression of SV40 large T antigen (SV40 TAg) exhibits a neuroendocrine phenotype. It is unclear whether SV40 TAg induces the neuroendocrine phenotype by preferential transformation of progenitor cells committed to the neuroendocrine lineage or by transcriptional activation of neuroendocrine genes. METHODOLOGY/PRINCIPAL FINDINGS: To address this...

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Identifiers

PMID: 22253802
DOI: 10.1371/journal.pone.0029846
PMCID: PMC3258231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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