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Article

Valproic Acid Addresses Neuroendocrine Differentiation of LNCaP Cells and Maintains Cell Survival.

Drug design, development and therapy - 1 Jan 2019

Giordano Francesca, Naimo Giuseppina Daniela, Nigro Alessandra, Romeo Francesco, Paolì Alessandro, De Amicis Francesca, Vivacqua Adele, Morelli Catia, Mauro Loredana, Panno Maria Luisa

Abstract excerpt

PURPOSE: Neuroendocrine differentiation of prostate cancer, induced by androgen deprivation therapy, is mainly related to advanced disease and poor clinical outcome. Genetic and epigenetic alterations are the key elements of the prostate carcinogenesis. A group of compounds able to induce changes in this sense is inhibitors of histone deacetylase, to which it belongs valproic acid (VPA). In the present paper, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31908413
DOI: 10.2147/DDDT.S229930
PMCID: PMC6927225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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