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Article

Engineering the rRNA decoding site of eukaryotic cytosolic ribosomes in bacteria.

Nucleic acids research - 1 Jan 2007

Hobbie Sven N, Kalapala Sarath K, Akshay Subramanian, Bruell Christian, Schmidt Sebastian, Dabow Sabine, Vasella Andrea, Sander Peter, Böttger Erik C

Abstract excerpt

Structural and genetic studies on prokaryotic ribosomes have provided important insights into fundamental aspects of protein synthesis and translational control and its interaction with ribosomal drugs. Comparable mechanistic studies in eukaryotes are mainly hampered by the absence of both high-resolution crystal structures and efficient genetic models. To study the interaction of aminoglycoside antibiotics with...

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Identifiers

PMID: 17766247
DOI: 10.1093/nar/gkm658
PMCID: PMC2094070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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