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Article

Effect of mutations in the A site of 16 S rRNA on aminoglycoside antibiotic-ribosome interaction.

Journal of molecular biology - 12 Feb 1999

Recht M I, Douthwaite S, Dahlquist K D, Puglisi J D

Abstract excerpt

Decoding of genetic information occurs upon interaction of an mRNA codon-tRNA anticodon complex with the small subunit of the ribosome. The ribosomal decoding region is associated with highly conserved sequences near the 3' end of 16 S rRNA. The decoding process is perturbed by the aminoglycoside antibiotics, which also interact with this region of rRNA. Mutations of certain nucleotides in rRNA reduce...

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Identifiers

PMID: 9931247
DOI: 10.1006/jmbi.1998.2446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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