Effect of mutations in the A site of 16 S rRNA on aminoglycoside antibiotic-ribosome interaction.

doi:10.1006/jmbi.1998.2446

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Article

Effect of mutations in the A site of 16 S rRNA on aminoglycoside antibiotic-ribosome interaction.

Journal of molecular biology - 12 Feb 1999

Recht M I, Douthwaite S, Dahlquist K D, Puglisi J D

Abstract excerpt

Decoding of genetic information occurs upon interaction of an mRNA codon-tRNA anticodon complex with the small subunit of the ribosome. The ribosomal decoding region is associated with highly conserved sequences near the 3' end of 16 S rRNA. The decoding process is perturbed by the aminoglycoside...

Topics

Anti-Bacterial Agents
Binding Sites
DNA, Bacterial
Escherichia coli
Mutagenesis, Site-Directed
Mutation
Nucleic Acid Conformation
Paromomycin
Phenotype
RNA, Ribosomal, 16S
Ribosomes

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