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Article

Aminoglycoside activity observed on single pre-translocation ribosome complexes.

Nature chemical biology - 1 Jan 2010

Feldman Michael B, Terry Daniel S, Altman Roger B, Blanchard Scott C

Abstract excerpt

Aminoglycoside-class antibiotics bind directly to ribosomal RNA, imparting pleiotropic effects on ribosome function. Despite in-depth structural investigations of aminoglycoside-RNA oligonucleotide and aminoglycoside-ribosome interactions, mechanisms explaining the unique ribosome inhibition profiles of chemically similar aminoglycosides remain elusive. Here, using single-molecule fluorescence resonance energy...

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Identifiers

PMID: 19946275
DOI: 10.1038/nchembio.274
PMCID: PMC2914512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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