Article
β-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): the first step towards an experimental model for sporadic ALS.
Environmental toxicology and pharmacology - 1 Sept 2013
de Munck Estefanía, Muñoz-Sáez Emma, Miguel Begoña G, Solas M Teresa, Ojeda Irene, Martínez Ana, Gil Carmen, Arahuetes Rosa Mª
Abstract excerpt
β-N-methylamino-l-alanine (L-BMAA) is a neurotoxic amino acid that has been related to various neurodegenerative diseases. The aim of this work was to analyze the biotoxicity produced by L-BMAA in vivo in rats, trying to elucidate its physiopathological mechanisms and to search for analogies between the found effects and pathologies like Amyotrophic Lateral Sclerosis (ALS). Our data demonstrated that the...
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