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Article

Thrombospondin-1 activates medial smooth muscle cells and triggers neointima formation upon mouse carotid artery ligation.

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2007

Moura Rute, Tjwa Marc, Vandervoort Petra, Cludts Katrien, Hoylaerts Marc F

Abstract excerpt

OBJECTIVE: Thrombospondin-1 (TSP1) is described as a positive regulator of vascular smooth muscle growth in cell culture. However, insight into the in vivo effects of TSP1 on smooth muscle cell (SMC) function is lacking. METHODS AND RESULTS: We analyzed wild-type (WT) and TSP1-deficient (Tsp1-/-) mice in a carotid artery ligation model, in which neointimal lesions form without overt mechanical damage to the...

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PMID: 17761938
DOI: 10.1161/ATVBAHA.107.151282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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