Article

Myeloid-Specific Thrombospondin-1 Deficiency Exacerbates Aortic Rupture via Broad Suppression of Extracellular Matrix Proteins

2024-07-31

Abstract excerpt

<h4>Rationale</h4> Rupture of abdominal aortic aneurysms (AAA) is associated with high mortality. However, the precise molecular and cellular drivers of AAA rupture remain elusive. Our prior study showed that global and myeloid-specific deletion of matricellular protein thrombospondin-1 (TSP1) protects mice from aneurysm formation primarily by inhibiting vascular inflammation. <h4>Objective</h4> To investigate t...

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Literature Corpus work: 8cadb589-bc19-5f4f-b46b-c7a9a12716bc
DOI: 10.1101/2024.07.30.605216

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Myeloid-Specific Thrombospondin-1 Deficiency Exacerbates Aortic Rupture via Broad Suppression of Extracellular Matrix ProteinsDOI 10.1101/2024.07.30.605216Read

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