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Article

Mutational events during the primary propagation and consecutive passages of hepatitis E virus strain JE03-1760F in cell culture.

Virus research - 1 Oct 2008

Lorenzo Felipe R, Tanaka Toshinori, Takahashi Hideyuki, Ichiyama Koji, Hoshino Yu, Yamada Kentaro, Inoue Jun, Takahashi Masaharu, Okamoto Hiroaki

Abstract excerpt

We recently developed a cell culture system for hepatitis E virus (HEV) in PLC/PRF/5 cells, using a genotype 3 HEV (JE03-1760F strain). Thirteen generations of consecutive passages of culture supernatant were successfully carried out in PLC/PRF/5 cells, with the highest HEV load reaching 10(8) copies/ml in the culture medium. Based on continuous release of progenies into culture medium, 50% tissue culture...

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Identifiers

PMID: 18620009
DOI: 10.1016/j.virusres.2008.06.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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