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Article

Mutational characteristics in consecutive passage of rapidly replicating variants of hepatitis A virus strain H2 during cell culture adaptation.

World journal of gastroenterology - 1 Oct 2002

Hu Ning-Zhu, Hu Yun-Zhang, Shi Hai-Jing, Liu Guo-Dong, Qu Su

Abstract excerpt

AIM: To investigate the molecular mechanism of cell adaptation and rapid replication of hepatitis A virus strain H2 in KBM17 cells. METHODS: Virus of strain H2 at passage 7 was consecutively passaged in KBM17 cells for 22 passages, every passage was incubated for 14 days. Antigenic and infectious...

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Identifiers

PMID: 12378633
DOI: 10.3748/wjg.v8.i5.872
PMCID: PMC4656578

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12378633-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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