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Article

Dec1 and CLOCK Regulate Na+/K+-ATPase β1 Subunit Expression and Blood Pressure.

Hypertension (Dallas, Tex. : 1979) - 1 Sept 2018

Nakashima Ayumu, Kawamoto Takeshi, Noshiro Mitsuhide, Ueno Toshinori, Doi Shigehiro, Honda Kiyomasa, Maruhashi Tatsuya, Noma Kensuke, Honma Sato, Masaki Takao, Higashi Yukihito, Kato Yukio

Abstract excerpt

Blood pressure shows a circadian rhythm, and recent studies have suggested the involvement of a molecular clock system in its control. In the clock system, the CLOCK (circadian locomotor output cycles kaput):BMAL1 (brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein-1) heterodimer enhances promoter activity of clock genes, and DEC1 (BHLHE40/STRA13/SHARP-2) represses CLOCK/BMAL1-enhanced...

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Identifiers

PMID: 30012868
DOI: 10.1161/HYPERTENSIONAHA.118.11075

Genes

CLOCK
BMAL1
BHLHE40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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