Article
A comprehensive contribution of genes for aryl hydrocarbon receptor signaling pathway to hypertension susceptibility.
Pharmacogenetics and genomics - 1 Feb 2017
Polonikov Alexey V, Bushueva Olga Yu, Bulgakova Irina V, Freidin Maxim B, Churnosov Mikhail I, Solodilova Maria A, Shvetsov Yaroslav D, Ivanov Vladimir P
Abstract excerpt
OBJECTIVE: The present study was designed to investigate whether genetic polymorphisms of the aryl hydrocarbon receptor (AHR) signaling pathway are involved in the molecular basis of essential hypertension (EH). METHODS: A total of 2160 unrelated Russian individuals comprising 1341 EH patients and 819 healthy controls were recruited into the study. Seven common AHR pathway single-nucleotide polymorphisms (SNPs)...
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