Article
Single molecule profiling of tau gene expression in Alzheimer's disease.
Journal of neurochemistry - 1 Nov 2007
Conrad Chris, Zhu Jun, Conrad Cintia, Schoenfeld David, Fang Zhide, Ingelsson Martin, Stamm Stefan, Church George, Hyman Bradley T
Abstract excerpt
Tau is a microtubule-associated protein that is important for establishing and maintaining neuronal morphology. In addition to its role in normal cells, tau protein is involved in many neurodegenerative diseases, e.g. Alzheimer's disease (AD) and frontotemporal dementia, as the main component of intraneuronal aggregates. Alternative splicing of tau gene in the brain can give rise to at least six protein variants....
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