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HCS-Splice: A High-Content Screening Method to Advance the Discovery of RNA Splicing-Modulating Therapeutics.

Cells - 28 Jul 2023

Covello Giuseppina, Siva Kavitha, Adami Valentina, Denti Michela Alessandra

Abstract excerpt

Nucleic acid therapeutics have demonstrated an impressive acceleration in recent years. They work through multiple mechanisms of action, including the downregulation of gene expression and the modulation of RNA splicing. While several drugs based on the former mechanism have been approved, few target the latter, despite the promise of RNA splicing modulation. To improve our ability to discover novel RNA...

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PMID: 37566038
DOI: 10.3390/cells12151959
PMCID: PMC10417277

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