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Article

Apolipoprotein E genotype influences vertical transmission of herpes simplex virus type 1 in a gender specific manner.

Aging cell - 1 Dec 2007

Burgos Javier S, Ramirez Carlos, Sastre Isabel, Valdivieso Fernando

Abstract excerpt

There is growing evidence that herpes simplex virus type 1 (HSV-1), together with the apolipoprotein E 4 (APOE4) allele, contribute to the pathogenesis of Alzheimer's disease (AD), although the mechanism of their interaction remains uncertain. Here we show that the combination of inherited APOE genotype and vertical transmission of HSV-1 confers a differential risk of brain infection. These risk factors are known...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17725689
DOI: 10.1111/j.1474-9726.2007.00332.x

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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