Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Herpes simplex virus type 1 in brain and risk of Alzheimer's disease.

Lancet (London, England) - 25 Jan 1997

Itzhaki R F, Lin W R, Shang D, Wilcock G K, Faragher B, Jamieson G A

Abstract excerpt

BACKGROUND: The apolipoprotein E epsilon 4 (APOE-epsilon 4) allele is a risk factor for Alzheimer's disease (AD), but it is neither essential nor sufficient for development of the disease. Other factors-genetic or environmental-must therefore have a role. By means of a PCR we have detected herpes...

Topics

Join the communities discussing this publication.

Aged
Aged, 80 and over
Brain
DNA, Viral
Genotype
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Source

Identifiers

PMID: 9014911
DOI: 10.1016/S0140-6736(96)10149-5

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-9014911-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Herpes simplex virus type 1 in brain and risk of Alzheimer's disease.PMID 9014911Read ↗

Interaction between APOE4 and herpes simplex virus type 1 in Alzheimer's diseaseSemantic proximity Read ↗

Neurotropic viruses and Alzheimer disease. Interaction of herpes simplex type 1 virus and apolipoprotein E in the etiology of the disease.Semantic proximity Read ↗

Herpesviruses in brain and Alzheimer's disease.Semantic proximity Read ↗

A genetic signature including apolipoprotein Eε4 potentiates the risk of herpes simplex–associated Alzheimer's diseaseSemantic proximity Read ↗

Herpes simplex virus type 1 and Alzheimerâ€™s disease: increasing evidence for a major role of the virusSemantic proximity Read ↗

Herpes simplex virus type 1, apolipoprotein E, and cholesterol: a dangerous liaison in Alzheimer's disease and other disorders.Semantic proximity Read ↗

Herpes simplex virus type I in brain and the type 4 allele of the apolipoprotein E gene are a combined risk factor for Alzheimer's disease.Semantic proximity Read ↗

Independent and Correlated Role of Apolipoprotein E ɛ4 Genotype and Herpes Simplex Virus Type 1 in Alzheimer's Disease.Semantic proximity Read ↗

HSV-1 in brain and risk of Alzheimer's diseaseSemantic proximity Read ↗

Alzheimer's disease, herpes simplex virus type 1, cold sores and apolipoprotein E4.Semantic proximity Read ↗

Herpes Simplex Virus 1 and the Risk of Dementia: A Population-Based StudySemantic proximity Read ↗

The role of viruses and of APOE in dementia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.