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Article

The essential role for c-Ski in mediating TGF-β1-induced bi-directional effects on skin fibroblast proliferation through a feedback loop

11 Dec 2007

Abstract excerpt

The bi-directional regulation of TGF-beta1 (transforming growth factor-beta1) on fibroblast proliferation with stimulation at low concentration, but inhibition at high concentration, has important significance during tissue repair. The mechanism has not been defined. c-Ski is a major co-repressor of TGF-beta1/Smad3 signalling; however, the exact role of c-Ski in the bi-directional regulation of fibroblast...

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PMID: 17725545
DOI: 10.1042/bj20070545

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Related research

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The essential role for c-Ski in mediating TGF-β1-induced bi-directional effects on skin fibroblast proliferation through a feedback loopPMID 17725545Read ↗

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Requirement of TGFβ Signaling for SMO-mediated CarcinogenesisSemantic proximity Read ↗

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