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Article

Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski.

Molecular biology of the cell - 1 Mar 2004

Takeda Masafumi, Mizuide Masafumi, Oka Masako, Watabe Tetsuro, Inoue Hirofumi, Suzuki Hiroyuki, Fujita Toshiro, Imamura Takeshi, Miyazono Kohei, Miyazawa Keiji

Abstract excerpt

c-Ski is a transcriptional corepressor that interacts strongly with Smad2, Smad3, and Smad4 but only weakly with Smad1 and Smad5. Through binding to Smad proteins, c-Ski suppresses signaling of transforming growth factor-beta (TGF-beta) as well as bone morphogenetic proteins (BMPs). In the present study, we found that a mutant of c-Ski, termed c-Ski (ARPG) inhibited TGF-beta/activin signaling but not BMP...

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Share to Bone Morphogenetic Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nerve Growth Factors

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Source

Open in PubMed Open full text

Identifiers

PMID: 14699069
DOI: 10.1091/mbc.e03-07-0478
PMCID: PMC363053

Genes

HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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