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Article

Prelamin A processing, accumulation and distribution in normal cells and laminopathy disorders.

Nucleus (Austin, Tex.) - 1 Jan 2016

Casasola Andrea, Scalzo David, Nandakumar Vivek, Halow Jessica, Recillas-Targa Félix, Groudine Mark, Rincón-Arano Héctor

Abstract excerpt

Lamin A is part of a complex structural meshwork located beneath the nuclear envelope and is involved in both structural support and the regulation of gene expression. Lamin A is initially expressed as prelamin A, which contains an extended carboxyl terminus that undergoes a series of post-translational modifications and subsequent cleavage by the endopeptidase ZMPSTE24 to generate lamin A. To facilitate...

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Source

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Identifiers

PMID: 26900797
DOI: 10.1080/19491034.2016.1150397
PMCID: PMC4916894

Genes

ZMPSTE24

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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