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Article

Altered splicing in prelamin A-associated premature aging phenotypes.

Progress in molecular and subcellular biology - 1 Jan 2006

De Sandre-Giovannoli Annachiara, Lévy Nicolas

Abstract excerpt

Hutchinson-Gilford progeria (HGPS), a rare and severe developmental disorder characterized by features recalling premature aging, and restrictive dermopathy (RD), a neonatal lethal genodermatosis, have recently been identified as being primary or secondary "laminopathies." These are heterogeneous disorders due to altered function of lamins A/C or related proteins. In physiological conditions, mature lamin A is...

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Source

Identifiers

PMID: 17076270
DOI: 10.1007/978-3-540-34449-0_9

Genes

LMNA
ZMPSTE24

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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