Article
Accumulation of distinct prelamin A variants in human diploid fibroblasts differentially affects cell homeostasis.
Experimental cell research - 1 Feb 2011
Candelario Jose, Borrego Stacey, Reddy Sita, Comai Lucio
Abstract excerpt
Lamin A is a component of the nuclear lamina that plays a major role in the structural organization and function of the nucleus. Lamin A is synthesized as a prelamin A precursor which undergoes four sequential post-translational modifications to generate mature lamin A. Significantly, a large number of point mutations in the LMNA gene cause a range of distinct human disorders collectively known as laminopathies....
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