Article
A novel technique for NOD2/CARD15 genotyping using PCR-SSP.
Journal of immunological methods - 31 Oct 2007
Mayor Neema P, Shaw Bronwen E, Keshav Satish, Madrigal J Alejandro, Marsh Steven G E
Abstract excerpt
The Nucleotide-binding Oligomerisation Domain (NOD) 2 protein is encoded by the Caspase Recruitment Domain (CARD) 15 gene and has a critical role in innate immunity. Recent studies have implicated Single Nucleotide Polymorphisms (SNPs) of the NOD2/CARD15 gene with the onset of several Inflammatory Bowel Disorders (Crohn's Disease, Blau syndrome) and the progression of several malignant diseases. The...
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