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Article

Identification and characterization of CYP3A4*20, a novel rare CYP3A4 allele without functional activity.

Clinical pharmacology and therapeutics - 1 Apr 2006

Westlind-Johnsson Anna, Hermann Robert, Huennemeyer Andreas, Hauns Bernhard, Lahu Gezim, Nassr Nassr, Zech Karl, Ingelman-Sundberg Magnus, von Richter Oliver

Abstract excerpt

BACKGROUND: The major drug-metabolizing enzyme cytochrome P450 (CYP) 3A4 is genetically conserved. One outlier of Brazilian descent was found in a clinical pharmacokinetic trial exhibiting a 6-fold higher exposure than expected to an investigational drug, shown to be a CYP3A4 substrate. We aimed...

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Source

Identifiers

PMID: 16580902
DOI: 10.1016/j.clpt.2005.11.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16580902-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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