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Article

Identification of a Hybrid PKS/NRPS Required for Pseurotin A Biosynthesis in the Human Pathogen <i>Aspergillus fumigatus</i>

24 Aug 2007

Abstract excerpt

The genome sequence of Aspergillus fumigatus revealed the presence of a single hybrid polyketide synthase-non-ribosomal peptide synthetase (PKS/NRPS) gene that is present within a cluster of five genes suggestive of its involvement in secondary metabolism. Here, we present evidence that it is required for the biosynthesis of pseurotin A, a compound with an unusual heterospirocyclic gamma-lactam structure. We have...

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PMID: 17722120
DOI: 10.1002/cbic.200700202

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