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Bacterium Induces Cryptic Meroterpenoid Pathway in the Pathogenic Fungus <i>Aspergillus fumigatus</i>

6 May 2013

Abstract excerpt

Stimulating encounter: The intimate, physical interaction between the soil-derived bacterium Streptomyces rapamycinicus and the human pathogenic fungus Aspergillus fumigatus led to the activation of an otherwise silent polyketide synthase (PKS) gene cluster coding for an unusual prenylated polyphenol (fumicycline A). The meroterpenoid pathway is regulated by a pathway-specific activator gene as well as by...

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PMID: 23649940
DOI: 10.1002/cbic.201300070

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