Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Illuminating the Diversity of Aromatic Polyketide Synthases in <i>Aspergillus nidulans</i>

17 Apr 2012

Abstract excerpt

Genome sequencing has revealed that fungi have the ability to synthesize many more natural products (NPs) than are currently known, but methods for obtaining suitable expression of NPs have been inadequate. We have developed a successful strategy that bypasses normal regulatory mechanisms. By efficient gene targeting, we have replaced, en masse, the promoters of nonreducing polyketide synthase (NR-PKS) genes, key...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fungal Biology and Applications
Share to Microbial Natural Products and Biosynthesis
Share to Plant Pathogens and Fungal Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22510154
DOI: 10.1021/ja3016395

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Illuminating the Diversity of Aromatic Polyketide Synthases in <i>Aspergillus nidulans</i>PMID 22510154Read ↗

Genetics of Polyketide Metabolism in Aspergillus nidulansSemantic proximity Read ↗

A genome-wide polyketide synthase deletion library uncovers novel genetic links to polyketides and meroterpenoids in Aspergillus nidulans.Semantic proximity Read ↗

Functional Analysis of the Polyketide Synthase Genes in the Filamentous Fungus<i>Gibberella zeae</i>(Anamorph<i>Fusarium graminearum</i>)Semantic proximity Read ↗

Evolution of Chemical Diversity in a Group of Non-Reduced Polyketide Gene Clusters: Using Phylogenetics to Inform the Search for Novel Fungal Natural ProductsSemantic proximity Read ↗

Discovery of Uncommon Tryptophan-Containing Diketopiperazines from Aspergillus homomorphus CBS 101889 Using an Aspergillus nidulans Heterologous Expression SystemSemantic proximity Read ↗

Genetic manipulation of secondary metabolite biosynthesis for improved production in <i>Streptomyces</i> and other actinomycetesSemantic proximity Read ↗

Discovery of a novel superfamily of type III polyketide synthases in Aspergillus oryzaeSemantic proximity Read ↗

Genome sequencing and molecular networking analysis of the wild fungus <i>Anthostomella pinea</i> reveal its ability to produce a diverse range of secondary metabolitesSemantic proximity Read ↗

The fungal transcription factor SmpR coordinates secondary metabolism and antibacterial defence in <i>Aspergillus fumigatus</i> during interspecies interactionSemantic proximity Read ↗

Heterologous Expression and Product Identification of<i>Colletotrichum lagenarium</i>Polyketide Synthase Encoded by the<i>PKS1</i>Gene Involved in Melanin BiosynthesisSemantic proximity Read ↗

Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans.Semantic proximity Read ↗

Phosphopantetheinyl transferase CfwA/NpgA is required for Aspergillus nidulans secondary metabolism and asexual development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.