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Oncogenic K-ras in Mouse Models of Myeloproliferative Disease and Acute Myeloid Leukemia

1 May 2004

Abstract excerpt

Oncogenic N-RAS and K-RAS mutations are among the most frequently detected genetic alterations in patients with acute myeloid leukemia (AML). Recently, the role of oncogenic K-ras in leukemogenesis was investigated in a novel mouse model utilizing interferon (IFN)-inducible, Cre-mediated expression of oncogenic K-ras from its endogenous promoter. Conditional expression of oncogenic K-ras from its endogenous...

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PMID: 15020838
DOI: 10.4161/cc.3.5.827

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