Mutational interference and the progression of Muller's ratchet when mutations have a broad range of deleterious effects.

doi:10.1534/genetics.107.073791

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Article

Mutational interference and the progression of Muller's ratchet when mutations have a broad range of deleterious effects.

Genetics - 1 Oct 2007

Söderberg R Jonas, Berg Otto G

Abstract excerpt

Deleterious mutations can accumulate in asexual haploid genomes through the process known as Muller's ratchet. This process has been described in the literature mostly for the case where all mutations are assumed to have the same effect on fitness. In the more realistic situation, deleterious mutations will affect fitness with a wide range of effects, from almost neutral to lethal. To elucidate the behavior of...

Topics

Adaptation, Physiological
Computer Simulation
Haploidy
Models, Genetic
Models, Theoretical
Mutation
Reproduction, Asexual
Selection, Genetic

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Identifiers

PMID: 17720933
DOI: 10.1534/genetics.107.073791
PMCID: PMC2034659

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