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Article

Fluctuations of fitness distributions and the rate of Muller's ratchet.

Genetics - 1 Aug 2012

Neher Richard A, Shraiman Boris I

Abstract excerpt

The accumulation of deleterious mutations is driven by rare fluctuations that lead to the loss of all mutation free individuals, a process known as Muller's ratchet. Even though Muller's ratchet is a paradigmatic process in population genetics, a quantitative understanding of its rate is still lacking. The difficulty lies in the nontrivial nature of fluctuations in the fitness distribution, which control the rate...

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Identifiers

PMID: 22649084
DOI: 10.1534/genetics.112.141325
PMCID: PMC3416007

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