Muller's ratchet and the degeneration of Y chromosomes: a simulation study.

doi:10.1534/genetics.108.092379

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Article

Muller's ratchet and the degeneration of Y chromosomes: a simulation study.

Genetics - 1 Oct 2008

Engelstädter Jan

Abstract excerpt

A typical pattern in sex chromosome evolution is that Y chromosomes are small and have lost many of their genes. One mechanism that might explain the degeneration of Y chromosomes is Muller's ratchet, the perpetual stochastic loss of linkage groups carrying the fewest number of deleterious mutations. This process has been investigated theoretically mainly for asexual, haploid populations. Here, I construct a...

Topics

Animals
Computer Simulation
Dosage Compensation, Genetic
Female
Haploidy
Humans
Male
Models, Genetic
Mutation
Recombination, Genetic
Reproduction, Asexual
Selection, Genetic
X Chromosome
Y Chromosome

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Identifiers

PMID: 18780738
DOI: 10.1534/genetics.108.092379
PMCID: PMC2567394

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