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Article

Muller's ratchet, epistasis and mutation effects.

Genetics - 1 Sept 1995

Butcher D

Abstract excerpt

In this study, computer simulation is used to show that despite synergistic epistasis for fitness, Muller's ratchet can lead to lethal fitness loss in a population of asexuals through the accumulation of deleterious mutations. This result contradicts previous work that indicated that epistasis will halt the ratchet. The present results show that epistasis will not halt the ratchet provided that rather than a...

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Identifiers

PMID: 8536988
DOI: 10.1093/genetics/141.1.431
PMCID: PMC1206738

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