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Article

Muller's ratchet, epistasis and mutation effects.

Genetics - 1 Sept 1995

Butcher D

Abstract excerpt

In this study, computer simulation is used to show that despite synergistic epistasis for fitness, Muller's ratchet can lead to lethal fitness loss in a population of asexuals through the accumulation of deleterious mutations. This result contradicts previous work that indicated that epistasis wi...

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Identifiers

PMID: 8536988
DOI: 10.1093/genetics/141.1.431
PMCID: PMC1206738

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-8536988-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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