Article
Rapid detection of common CARD15 variants in patients with inflammatory bowel disease.
Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology - 1 Jan 2004
Roberts Rebecca L, Gearry Richard B, Barclay Murray L, Kennedy Martin A
Abstract excerpt
BACKGROUND: Three mutations (R702W, G908R, and 1007fs) within the CARD15 gene have been identified as independent risk factors for the development of Crohn's disease (CD). Virtually all studies investigating the occurrence of these mutations in patients with CD have used separate PCR-based methods to screen patient DNA, here we describe a novel multiplex amplification refractory mutation system (ARMS) assay that...
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