Article
Growing dendrites and axons differ in their reliance on the secretory pathway.
Cell - 24 Aug 2007
Ye Bing, Zhang Ye, Song Wei, Younger Susan H, Jan Lily Yeh, Jan Yuh Nung
Abstract excerpt
Little is known about how the distinct architectures of dendrites and axons are established. From a genetic screen, we isolated dendritic arbor reduction (dar) mutants with reduced dendritic arbors but normal axons of Drosophila neurons. We identified dar2, dar3, and dar6 genes as the homologs of Sec23, Sar1, and Rab1 of the secretory pathway. In both Drosophila and rodent neurons, defects in Sar1 expression...
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