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Article

The calcineurin-NFAT pathway negatively regulates megakaryopoiesis

28 Feb 2013

Abstract excerpt

The calcium regulated calcineurin-nuclear factor of activated T cells (NFAT) pathway modulates the physiology of numerous cell types, including hematopoietic. Upon activation, calcineurin dephosphorylates NFAT family transcription factors, triggering their nuclear entry and activation or repression of target genes. NFATc1 and c2 isoforms are expressed in megakaryocytes. Moreover, human chromosome 21 (Hsa21)...

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PMID: 23446734
DOI: 10.1182/blood-2012-04-421172

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