BET inhibition prevents aberrant RUNX1 and ERG transcription in STAG2 mutant leukaemia cells

Abstract excerpt

Dear Editor, Cohesin is a multiprotein complex that not only is essential for cell division but also has key roles in genome organization that underpin its gene regulatory function. Recurrent mutations of genes encoding cohesin subunits occur in myeloid malignancies at 10%–12% (Kon et al., 2013), and the frequency of cohesin mutation in Down syndrome-associated megakaryoblastic leukaemia is even higher (~50%)...

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