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Article

Down-regulation of the trypanosomatid signal recognition particle affects the biogenesis of polytopic membrane proteins but not of signal peptide-containing proteins.

Eukaryotic cell - 1 Oct 2007

Lustig Yaniv, Vagima Yaron, Goldshmidt Hanoch, Erlanger Avigail, Ozeri Vered, Vince James, McConville Malcolm J, Dwyer Dennis M, Landfear Scott M, Michaeli Shulamit

Abstract excerpt

Protein translocation across the endoplasmic reticulum is mediated by the signal recognition particle (SRP). In this study, the SRP pathway in trypanosomatids was down-regulated by two approaches: RNA interference (RNAi) silencing of genes encoding SRP proteins in Trypanosoma brucei and overexpression of dominant-negative mutants of 7SL RNA in Leptomonas collosoma. The biogenesis of both signal peptide-containing...

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Source

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Identifiers

PMID: 17715370
DOI: 10.1128/EC.00134-07
PMCID: PMC2043396

Genes

SRP54
SRP68

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Down-regulation of the trypanosomatid signal recognition particle affects the biogenesis of polytopic membrane proteins but not of signal peptide-containing proteins.PMID 17715370Read ↗

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