Article
Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia.
Blood - 28 Aug 2014
Kiel Mark J, Velusamy Thirunavukkarasu, Rolland Delphine, Sahasrabuddhe Anagh A, Chung Fuzon, Bailey Nathanael G, Schrader Alexandra, Li Bo, Li Jun Z, Ozel Ayse B, Betz Bryan L, Miranda Roberto N, Medeiros L Jeffrey, Zhao Lili, Herling Marco, Lim Megan S, Elenitoba-Johnson Kojo S J
Abstract excerpt
The comprehensive genetic alterations underlying the pathogenesis of T-cell prolymphocytic leukemia (T-PLL) are unknown. To address this, we performed whole-genome sequencing (WGS), whole-exome sequencing (WES), high-resolution copy-number analysis, and Sanger resequencing of a large cohort of T-PLL. WGS and WES identified novel mutations in recurrently altered genes not previously implicated in T-PLL including...
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