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Article

Identification and characterization of human cdc7 nuclear retention and export sequences in the context of chromatin binding.

The Journal of biological chemistry - 12 Oct 2007

Kim Byung Ju, Kim So-Young, Lee Hoyun

Abstract excerpt

The Cdc7 serine/threonine kinase activates the initiation of DNA replication by phosphorylating MCM proteins that are bound to the origins of DNA replication. We reported previously that human Cdc7 nuclear import is mediated directly by importin-beta through its binding to the Cdc7 nuclear localization sequence (NLS). Here, we report that human Cdc7 nuclear localization is regulated by two additional elements:...

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Identifiers

PMID: 17711849
DOI: 10.1074/jbc.M703705200

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NES

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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