Article
A Genome-Wide Association Study of Respiratory Syncytial Virus Infection Severity in Infants.
The Journal of infectious diseases - 1 Mar 2024
Johnson Mari, Chelysheva Irina, Öner Deniz, McGinley Joseph, Lin Gu-Lung, O'Connor Daniel, Robinson Hannah, Drysdale Simon B, Gammin Emma, Vernon Sophie, Muller Jill, Wolfenden Helen, Westcar Sharon, Anguvaa Lazarus, Thwaites Ryan S, Bont Louis, Wildenbeest Joanne, Martinón-Torres Federico, Aerssens Jeroen, Openshaw Peter J M, Pollard Andrew J
Abstract excerpt
BACKGROUND: Respiratory syncytial virus (RSV) is a significant cause of infant morbidity and mortality worldwide. Most children experience at least one 1 RSV infection by the age of two 2 years, but not all develop severe disease. However, the understanding of genetic risk factors for severe RSV is incomplete. Consequently, we conducted a genome-wide association study of RSV severity. METHODS: Disease severity...
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