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Viral Genetic Determinants of Prolonged Respiratory Syncytial Virus Infection Among Infants in a Healthy Term Birth Cohort.

The Journal of infectious diseases - 12 May 2023

Lawless Dylan, McKennan Christopher G, Das Suman R, Junier Thomas, Xu Zhi Ming, Anderson Larry J, Gebretsadik Tebeb, Shilts Meghan H, Larkin Emma, Rosas-Salazar Christian, Chappell James D, Fellay Jacques, Hartert Tina V

Abstract excerpt

BACKGROUND: Respiratory syncytial virus (RSV) is associated with acute respiratory infection. We sought to identify RSV variants associated with prolonged infection. METHODS: Among healthy term infants we identified those with prolonged RSV infection and conducted (1) a human genome-wide association study (GWAS) to test the dependence of infection risk on host genotype, (2) a viral GWAS for association with...

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Identifiers

PMID: 36375000
DOI: 10.1093/infdis/jiac442
PMCID: PMC10175068

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