Article
Great genotypic and phenotypic diversities associated with copy-number variations of complement C4 and RP-C4-CYP21-TNX (RCCX) modules: a comparison of Asian-Indian and European American populations.
Molecular immunology - 1 Apr 2009
Saxena Kapil, Kitzmiller Kathryn J, Wu Yee Ling, Zhou Bi, Esack Nazreen, Hiremath Leena, Chung Erwin K, Yang Yan, Yu C Yung
Abstract excerpt
Inter-individual gene copy-number variations (CNVs) probably afford human populations the flexibility to respond to a variety of environmental challenges, but also lead to differential disease predispositions. We investigated gene CNVs for complement component C4 and steroid 21-hydroxylase from the RP-C4-CYP21-TNX (RCCX) modules located in the major histocompatibility complex among healthy Asian-Indian Americans...
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