Article
Folic acid and vitamin B-12 supplementation does not favorably influence uracil incorporation and promoter methylation in rectal mucosa DNA of subjects with previous colorectal adenomas.
The Journal of nutrition - 1 Sept 2007
van den Donk Maureen, Pellis Linette, Crott Jimmy W, van Engeland Manon, Friederich Pieter, Nagengast Fokko M, van Bergeijk Jeroen D, de Boer Sybrand Y, Mason Joel B, Kok Frans J, Keijer Jaap, Kampman Ellen
Abstract excerpt
Adequate folate availability is necessary to sustain normal DNA synthesis and normal patterns of DNA methylation and these features of DNA can be modified by methylenetetrahydrofolate reductase (MTHFR) C677T genotype. This study investigated the effect of MTHFR C677T genotype and daily supplement...
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