Article
Lack of association between the C677T MTHFR polymorphism and colorectal hyperplastic polyps.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2000
Ulrich C M, Kampman E, Bigler J, Schwartz S M, Chen C, Bostick R, Fosdick L, Beresford S A, Yasui Y, Potter J D
Abstract excerpt
Colorectal hyperplastic polyps are benign lesions that share many risk factors with colorectal adenomas and cancers. Low folate intakes are associated with an increased risk of colon cancer. The enzyme 5,10-methylene-tetrahydrofolate reductase (MTHFR) may be linked to DNA methylation and nucleotide synthesis and thus play a role in the etiology of colorectal neoplasia. We investigated an association between the...
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