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Article

MTHFR (C677T) polymorphisms and stage III colon cancer: response to therapy.

Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology - 1 Jun 1999

Wisotzkey J D, Toman J, Bell T, Monk J S, Jones D

Abstract excerpt

BACKGROUND: Leucovorin and 5-fluorouracil (5-FU) chemotherapeutics are often used as coinhibitors of the thymidylate synthase pathway to thwart the growth of cancer cells in certain types of neoplasms. The metabolism of leucovorin is mediated through the enzyme methylenetetrahydrofolate reductase (MTHFR). A common polymorphism in the MTHFR gene has been reported to be responsible for as much as a 70% reduction in...

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Identifiers

PMID: 10462625
DOI: 10.1016/s1084-8592(99)80034-4

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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