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Article

Association of MTHFR gene polymorphisms with breast cancer survival.

BMC cancer - 27 Oct 2006

Martin Damali N, Boersma Brenda J, Howe Tiffany M, Goodman Julie E, Mechanic Leah E, Chanock Stephen J, Ambs Stefan

Abstract excerpt

BACKGROUND: Two functional single nucleotide polymorphisms (SNPs) in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C, lead to decreased enzyme activity and affect chemosensitivity of tumor cells. We investigated whether these MTHFR SNPs were associated with breast cancer survival in African-American and Caucasian women. METHODS: African-American (n = 143) and Caucasian (n = 105) women,...

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Source

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Identifiers

PMID: 17069650
DOI: 10.1186/1471-2407-6-257
PMCID: PMC1634868

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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