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Article

Oxidized phospholipids induce type VIII collagen expression and vascular smooth muscle cell migration.

Circulation research - 13 Mar 2009

Cherepanova Olga A, Pidkovka Nataliya A, Sarmento Olga F, Yoshida Tadashi, Gan Qiong, Adiguzel Eser, Bendeck Michelle P, Berliner Judith, Leitinger Norbert, Owens Gary K

Abstract excerpt

Phenotypic switching of vascular smooth muscle cells (VSMCs) is known to play a critical role in the development of atherosclerosis. However, the factors present within lesions that mediate VSMC phenotypic switching are unclear. Oxidized phospholipids (OxPLs), including 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC), are active components of minimally modified low density lipoprotein and...

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PMID: 19168440
DOI: 10.1161/CIRCRESAHA.108.186064
PMCID: PMC2758767

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