Article
Control of lymphocyte infiltration of lung tumors in mice by host's genes: mapping of four Lynf (lymphocyte infiltration) loci.
Cancer immunology, immunotherapy : CII - 1 Feb 2008
Kakarlapudi Neelima, Vernooy Juanita H J, Quan Lei, Fijneman Remond J A, Demant Peter
Abstract excerpt
Tumor infiltration by lymphocytes is essential for cell-mediated immune elimination of tumors in experimental systems and in immunotherapy of cancer. Presence of lymphocytes in several human cancers has been associated with a better prognosis. We present evidence that individual propensity to tumor infiltration is genetically controlled. Infiltrating lymphocytes are present in 50% of lung tumors in O20/A mice,...
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