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Article

Revealing Putative Causal Genes by Establishing the Causality Between Different Lymphomas and Immune Cells.

Journal of cellular and molecular medicine - 1 May 2025

Lian Jingxuan, Zhang Xinghong, Chen Wenjie, Lin Zheshen, Lu Ming, Liang Rong

Abstract excerpt

The tumour immune microenvironment (TIME) is critical for lymphoma progression and therapy resistance, yet causal relationships between specific immune cell types and lymphoma subtypes remain poorly defined. In this study, using bidirectional Mendelian randomization (MR), genetic correlation (LDSC), and expression-QTL integration (SMR), we systematically evaluated causal relationships and genetic correlation...

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Share to Gene Expression Regulation, Neoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Linkage Disequilibrium

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 40360443
DOI: 10.1111/jcmm.70535
PMCID: PMC12074867

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