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Article

Forerunner genes contiguous to RB1 contribute to the development of <i>in situ</i> neoplasia

16 Aug 2007

Abstract excerpt

We used human bladder cancer as a model system and the whole-organ histologic and genetic mapping strategy to identify clonal genetic hits associated with growth advantage, tracking the evolution of bladder cancer from intraurothelial precursor lesions. Six putative chromosomal regions critical for clonal expansion of intraurothelial neoplasia and development of bladder cancer were identified by using this...

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Share to Bladder and Urothelial Cancer Treatments
Share to Epigenetics and DNA Methylation
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PMID: 17702869
DOI: 10.1073/pnas.0701771104

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